Linking spherical mean diffusion weighted signal with intra-axonal volume fraction

Mapping mean axon diameter and axonal volume fraction by MRI using temporal diffusion spectroscopy

Mapping mean axon diameter and intra-axonal volume fraction may have significant clinical potential because nerve conduction velocity is directly dependent on axon diameter, and several neurodegenerative diseases affect axons of specific sizes and alter axon counts. Diffusion-weighted MRI methods based on the pulsed gradient spin echo (PGSE) sequence have been reported to be able to assess axon...

Signal Intensity of High B-value Diffusion-weighted Imaging for the Detection of Prostate Cancer

Background: Diffusion-weighted imaging (DWI) is a main component of multiparametric MRI for prostate cancer detection. Recently, high b value DWI has gained more attention because of its capability for tumor characterization. Objective: To assess based on histopathological findings of transrectal ultrasound (TRUS)-guided prostate biopsy as a reference, an...

Evaluation of volume-weighted mean nuclear volume in endometrial lesions.

The individual nuclear size was studied in three groups of endometrial samples (simple hyperplasia -SH-, atypical hyperplasia -AH-, and well-differentiated adenocarcinoma -WDA-). The application of recent semiquantitative systems in combination with stereological methods permits a simple, quick and unbiased estimation of the volume-weighted mean nuclear volume vv(nucl). We have found an increas...

Multi-Spherical Diffusion MRI: Exploring Diffusion Time Using Signal Sparsity

Effective representation of the diffusion signal’s dependence on diffusion time is a sought-after, yet still unsolved, challenge in diffusion MRI (dMRI). We propose a functional basis approach that is specifically designed to represent the dMRI signal in this four-dimensional space – varying over gradient strength, direction and diffusion time. In particular, we provide regularization tools imp...

Diffusion weighted imaging with background signal suppression in breast cancer